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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of TurboFold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & TurboFold(20) [.zip] - may take several seconds...


Overview

Metric Cylofold TurboFold(20)
MCC 0.756 > 0.750
Average MCC ± 95% Confidence Intervals 0.801 ± 0.302 > 0.757 ± 0.116
Sensitivity 0.723 > 0.670
Positive Predictive Value 0.802 < 0.852
Total TP 81 > 75
Total TN 4703 < 4716
Total FP 21 > 14
Total FP CONTRA 6 > 5
Total FP INCONS 14 > 8
Total FP COMP 1 = 1
Total FN 31 < 37
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and TurboFold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and TurboFold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and TurboFold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and TurboFold(20)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 81
Total TN 4703
Total FP 21
Total FP CONTRA 6
Total FP INCONS 14
Total FP COMP 1
Total FN 31
Total Scores
MCC 0.756
Average MCC ± 95% Confidence Intervals 0.801 ± 0.302
Sensitivity 0.723
Positive Predictive Value 0.802
Nr of predictions 5

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of TurboFold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 75
Total TN 4716
Total FP 14
Total FP CONTRA 5
Total FP INCONS 8
Total FP COMP 1
Total FN 37
Total Scores
MCC 0.750
Average MCC ± 95% Confidence Intervals 0.757 ± 0.116
Sensitivity 0.670
Positive Predictive Value 0.852
Nr of predictions 5

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.