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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Cylofold TurboFold(seed)
MCC 0.740 > 0.641
Average MCC ± 95% Confidence Intervals 0.773 ± 0.239 > 0.626 ± 0.349
Sensitivity 0.708 > 0.577
Positive Predictive Value 0.786 > 0.728
Total TP 92 > 75
Total TN 5215 < 5229
Total FP 26 < 29
Total FP CONTRA 7 < 8
Total FP INCONS 18 < 20
Total FP COMP 1 = 1
Total FN 38 < 55
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and TurboFold(seed)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 92
Total TN 5215
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 38
Total Scores
MCC 0.740
Average MCC ± 95% Confidence Intervals 0.773 ± 0.239
Sensitivity 0.708
Positive Predictive Value 0.786
Nr of predictions 6

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 75
Total TN 5229
Total FP 29
Total FP CONTRA 8
Total FP INCONS 20
Total FP COMP 1
Total FN 55
Total Scores
MCC 0.641
Average MCC ± 95% Confidence Intervals 0.626 ± 0.349
Sensitivity 0.577
Positive Predictive Value 0.728
Nr of predictions 6

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.