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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of IPknot - scored higher in this pairwise comparison

  4. Performance of MXScarna(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for IPknot & MXScarna(20) [.zip] - may take several seconds...


Overview

Metric IPknot MXScarna(20)
MCC 0.623 > 0.606
Average MCC ± 95% Confidence Intervals 0.636 ± 0.265 > 0.580 ± 0.272
Sensitivity 0.591 > 0.561
Positive Predictive Value 0.667 = 0.667
Total TP 78 > 74
Total TN 9203 < 9209
Total FP 48 < 59
Total FP CONTRA 11 < 16
Total FP INCONS 28 > 21
Total FP COMP 9 < 22
Total FN 54 < 58
P-value 0.0

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Performance plots


  1. Comparison of performance of IPknot and MXScarna(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and MXScarna(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and MXScarna(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and MXScarna(20)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP 78
Total TN 9203
Total FP 48
Total FP CONTRA 11
Total FP INCONS 28
Total FP COMP 9
Total FN 54
Total Scores
MCC 0.623
Average MCC ± 95% Confidence Intervals 0.636 ± 0.265
Sensitivity 0.591
Positive Predictive Value 0.667
Nr of predictions 6

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.74 0.69 0.80 20 1508 5 0 5 0 9
4A1C_2 0.23 0.25 0.22 5 4493 26 8 10 8 15
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.59 0.53 0.67 8 484 4 0 4 0 7

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Performance of MXScarna(20) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 74
Total TN 9209
Total FP 59
Total FP CONTRA 16
Total FP INCONS 21
Total FP COMP 22
Total FN 58
Total Scores
MCC 0.606
Average MCC ± 95% Confidence Intervals 0.580 ± 0.272
Sensitivity 0.561
Positive Predictive Value 0.667
Nr of predictions 6

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.74 0.76 0.73 22 1503 9 6 2 1 7
4A1C_2 0.22 0.25 0.21 5 4492 36 8 11 17 15
4AOB_A 0.68 0.69 0.69 20 1408 13 2 7 4 9
4ENB_A 0.29 0.13 0.67 2 469 1 0 1 0 13
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.