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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MCFold - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MCFold & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric MCFold PPfold(seed)
MCC 0.491 > 0.173
Average MCC ± 95% Confidence Intervals 0.510 ± 0.284 > 0.098 ± 0.206
Sensitivity 0.521 > 0.058
Positive Predictive Value 0.477 < 0.538
Total TP 63 > 7
Total TN 8279 < 8398
Total FP 90 > 25
Total FP CONTRA 13 > 0
Total FP INCONS 56 > 6
Total FP COMP 21 > 19
Total FN 58 < 114
P-value 0.0

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Performance plots


  1. Comparison of performance of MCFold and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MCFold and PPfold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for MCFold and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MCFold and PPfold(seed)).

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Performance of MCFold - scored higher in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 63
Total TN 8279
Total FP 90
Total FP CONTRA 13
Total FP INCONS 56
Total FP COMP 21
Total FN 58
Total Scores
MCC 0.491
Average MCC ± 95% Confidence Intervals 0.510 ± 0.284
Sensitivity 0.521
Positive Predictive Value 0.477
Nr of predictions 6

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.44 0.47 8 511 10 0 9 1 10
3RKF_A 0.89 0.88 0.91 21 843 3 0 2 1 3
3SD1_A 0.43 0.45 0.43 13 1503 17 1 16 0 16
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 7
Total TN 8398
Total FP 25
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 19
Total FN 114
Total Scores
MCC 0.173
Average MCC ± 95% Confidence Intervals 0.098 ± 0.206
Sensitivity 0.058
Positive Predictive Value 0.538
Nr of predictions 6

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.49 0.33 0.75 6 520 2 0 2 0 12
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
4A1C_2 0.10 0.05 0.20 1 4511 23 0 4 19 19
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.