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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & Murlet(20) [.zip] - may take several seconds...


Overview

Metric MXScarna(20) Murlet(20)
MCC 0.703 > 0.666
Average MCC ± 95% Confidence Intervals 0.698 ± 0.114 > 0.679 ± 0.114
Sensitivity 0.659 > 0.548
Positive Predictive Value 0.755 < 0.814
Total TP 299 > 249
Total TN 51867 < 51957
Total FP 147 > 79
Total FP CONTRA 49 > 17
Total FP INCONS 48 > 40
Total FP COMP 50 > 22
Total FN 155 < 205
P-value 2.66715895098e-08

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Performance plots


  1. Comparison of performance of MXScarna(20) and Murlet(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and Murlet(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and Murlet(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and Murlet(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and Murlet(20)).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 299
Total TN 51867
Total FP 147
Total FP CONTRA 49
Total FP INCONS 48
Total FP COMP 50
Total FN 155
Total Scores
MCC 0.703
Average MCC ± 95% Confidence Intervals 0.698 ± 0.114
Sensitivity 0.659
Positive Predictive Value 0.755
Nr of predictions 15

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.74 0.73 0.76 16 1087 6 1 4 1 6
3GX2_A 0.81 0.79 0.85 22 1423 6 2 2 2 6
3IVN_B 0.81 0.74 0.89 17 884 2 2 0 0 6
3IZ4_A 0.58 0.54 0.63 51 25455 35 18 12 5 44
3JYV_7 0.95 0.90 1.00 18 1093 2 0 0 2 2
3LA5_A 0.87 0.80 0.95 20 933 1 1 0 0 5
3NPB_A 0.77 0.73 0.82 27 2245 9 2 4 3 10
3O58_3 0.62 0.59 0.65 13 4744 18 5 2 11 9
3PDR_A 0.85 0.82 0.89 41 4794 9 2 3 4 9
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.74 0.76 0.73 22 1503 9 6 2 1 7
4A1C_2 0.22 0.25 0.21 5 4492 36 8 11 17 15
4AOB_A 0.68 0.69 0.69 20 1408 13 2 7 4 9
4ENB_A 0.29 0.13 0.67 2 469 1 0 1 0 13
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Performance of Murlet(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 249
Total TN 51957
Total FP 79
Total FP CONTRA 17
Total FP INCONS 40
Total FP COMP 22
Total FN 205
Total Scores
MCC 0.666
Average MCC ± 95% Confidence Intervals 0.679 ± 0.114
Sensitivity 0.548
Positive Predictive Value 0.814
Nr of predictions 15

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3A2K_C 0.88 0.86 0.90 19 1087 2 0 2 0 3
3GX2_A 0.73 0.54 1.00 15 1434 1 0 0 1 13
3IVN_B 0.80 0.65 1.00 15 888 0 0 0 0 8
3IZ4_A 0.46 0.33 0.66 31 25489 22 3 13 6 64
3JYV_7 0.84 0.80 0.89 16 1093 4 0 2 2 4
3LA5_A 0.80 0.64 1.00 16 938 0 0 0 0 9
3NPB_A 0.65 0.43 1.00 16 2262 2 0 0 2 21
3O58_3 0.37 0.32 0.44 7 4748 13 4 5 4 15
3PDR_A 0.84 0.76 0.93 38 4799 3 1 2 0 12
3RKF_A 0.81 0.67 1.00 16 850 0 0 0 0 8
3SD1_A 0.82 0.83 0.83 24 1504 5 4 1 0 5
4A1C_2 0.22 0.25 0.20 5 4491 24 5 15 4 15
4AOB_A 0.87 0.76 1.00 22 1415 3 0 0 3 7
4ENB_A 0.51 0.27 1.00 4 468 0 0 0 0 11
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.