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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric MXScarna(20) NanoFolder
MCC 0.512 > 0.285
Average MCC ± 95% Confidence Intervals 0.528 ± 0.654 > 0.346 ± 0.831
Sensitivity 0.500 > 0.359
Positive Predictive Value 0.533 > 0.240
Total TP 32 > 23
Total TN 6389 > 6353
Total FP 49 < 90
Total FP CONTRA 10 < 24
Total FP INCONS 18 < 49
Total FP COMP 21 > 17
Total FN 32 < 41
P-value 0.0

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Performance plots


  1. Comparison of performance of MXScarna(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and NanoFolder).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 32
Total TN 6389
Total FP 49
Total FP CONTRA 10
Total FP INCONS 18
Total FP COMP 21
Total FN 32
Total Scores
MCC 0.512
Average MCC ± 95% Confidence Intervals 0.528 ± 0.654
Sensitivity 0.500
Positive Predictive Value 0.533
Nr of predictions 3

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.22 0.25 0.21 5 4492 36 8 11 17 15
4AOB_A 0.68 0.69 0.69 20 1408 13 2 7 4 9
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 23
Total TN 6353
Total FP 90
Total FP CONTRA 24
Total FP INCONS 49
Total FP COMP 17
Total FN 41
Total Scores
MCC 0.285
Average MCC ± 95% Confidence Intervals 0.346 ± 0.831
Sensitivity 0.359
Positive Predictive Value 0.240
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.