CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Vsfold4 [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Vsfold4
MCC 0.711 > 0.531
Average MCC ± 95% Confidence Intervals 0.691 ± 0.117 > 0.577 ± 0.166
Sensitivity 0.663 > 0.530
Positive Predictive Value 0.768 > 0.538
Total TP 381 > 305
Total TN 77219 > 77148
Total FP 184 < 307
Total FP CONTRA 60 < 83
Total FP INCONS 55 < 179
Total FP COMP 69 > 45
Total FN 194 < 270
P-value 2.78993384543e-08

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Vsfold4).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 381
Total TN 77219
Total FP 184
Total FP CONTRA 60
Total FP INCONS 55
Total FP COMP 69
Total FN 194
Total Scores
MCC 0.711
Average MCC ± 95% Confidence Intervals 0.691 ± 0.117
Sensitivity 0.663
Positive Predictive Value 0.768
Nr of predictions 19

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 518 12 0 10 2 18
2ZZN_D 0.95 0.91 1.00 20 964 0 0 0 0 2
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.84 0.77 0.92 23 1475 4 0 2 2 7
3GX2_A 0.83 0.82 0.85 23 1422 7 2 2 3 5
3IVN_B 0.69 0.57 0.87 13 888 2 2 0 0 10
3IYQ_A 0.44 0.47 0.41 24 22382 49 21 13 15 27
3IZ4_A 0.73 0.64 0.82 61 25462 22 12 1 9 34
3JYV_7 0.95 0.90 1.00 18 1093 2 0 0 2 2
3LA5_A 0.82 0.72 0.95 18 935 1 1 0 0 7
3NPB_A 0.76 0.70 0.84 26 2247 10 2 3 5 11
3O58_3 0.54 0.50 0.58 11 4745 20 5 3 12 11
3PDR_A 0.87 0.88 0.86 44 4789 10 4 3 3 6
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.74 0.76 0.73 22 1503 9 4 4 1 7
4A1C_2 0.45 0.40 0.50 8 4500 20 4 4 12 12
4AOB_A 0.71 0.69 0.74 20 1410 10 2 5 3 9
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.48 0.40 0.60 6 486 4 1 3 0 9

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 305
Total TN 77148
Total FP 307
Total FP CONTRA 83
Total FP INCONS 179
Total FP COMP 45
Total FN 270
Total Scores
MCC 0.531
Average MCC ± 95% Confidence Intervals 0.577 ± 0.166
Sensitivity 0.530
Positive Predictive Value 0.538
Nr of predictions 19

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3GX2_A 0.60 0.57 0.64 16 1424 10 0 9 1 12
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IYQ_A 0.27 0.35 0.21 18 22353 80 40 29 11 33
3IZ4_A 0.39 0.39 0.39 37 25441 63 15 43 5 58
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.66 0.59 0.73 22 2248 10 0 8 2 15
3O58_3 0.12 0.14 0.11 3 4737 35 8 16 11 19
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.23 0.24 0.24 7 1504 22 5 17 0 22
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.