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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & MCFold [.zip] - may take several seconds...


Overview

Metric Multilign(20) MCFold
MCC 0.580 > 0.498
Average MCC ± 95% Confidence Intervals 0.583 ± 0.354 > 0.525 ± 0.373
Sensitivity 0.583 > 0.534
Positive Predictive Value 0.588 > 0.478
Total TP 60 > 55
Total TN 7781 > 7768
Total FP 50 < 80
Total FP CONTRA 14 > 13
Total FP INCONS 28 < 47
Total FP COMP 8 < 20
Total FN 43 < 48
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and MCFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and MCFold).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 60
Total TN 7781
Total FP 50
Total FP CONTRA 14
Total FP INCONS 28
Total FP COMP 8
Total FN 43
Total Scores
MCC 0.580
Average MCC ± 95% Confidence Intervals 0.583 ± 0.354
Sensitivity 0.583
Positive Predictive Value 0.588
Nr of predictions 5

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 55
Total TN 7768
Total FP 80
Total FP CONTRA 13
Total FP INCONS 47
Total FP COMP 20
Total FN 48
Total Scores
MCC 0.498
Average MCC ± 95% Confidence Intervals 0.525 ± 0.373
Sensitivity 0.534
Positive Predictive Value 0.478
Nr of predictions 5

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.89 0.88 0.91 21 843 3 0 2 1 3
3SD1_A 0.43 0.45 0.43 13 1503 17 1 16 0 16
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.