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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Multilign(20) NanoFolder
MCC 0.456 > 0.285
Average MCC ± 95% Confidence Intervals 0.504 ± 0.685 > 0.346 ± 0.831
Sensitivity 0.469 > 0.359
Positive Predictive Value 0.455 > 0.240
Total TP 30 > 23
Total TN 6383 > 6353
Total FP 44 < 90
Total FP CONTRA 13 < 24
Total FP INCONS 23 < 49
Total FP COMP 8 < 17
Total FN 34 < 41
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 30
Total TN 6383
Total FP 44
Total FP CONTRA 13
Total FP INCONS 23
Total FP COMP 8
Total FN 34
Total Scores
MCC 0.456
Average MCC ± 95% Confidence Intervals 0.504 ± 0.685
Sensitivity 0.469
Positive Predictive Value 0.455
Nr of predictions 3

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 23
Total TN 6353
Total FP 90
Total FP CONTRA 24
Total FP INCONS 49
Total FP COMP 17
Total FN 41
Total Scores
MCC 0.285
Average MCC ± 95% Confidence Intervals 0.346 ± 0.831
Sensitivity 0.359
Positive Predictive Value 0.240
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.