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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Fold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Fold [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Fold
MCC 0.629 > 0.589
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654 > 0.541 ± 0.642
Sensitivity 0.580 > 0.570
Positive Predictive Value 0.699 > 0.626
Total TP 58 > 57
Total TN 4281 > 4273
Total FP 26 < 35
Total FP CONTRA 7 < 11
Total FP INCONS 18 < 23
Total FP COMP 1 = 1
Total FN 42 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Fold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Fold).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of Fold - scored lower in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP 57
Total TN 4273
Total FP 35
Total FP CONTRA 11
Total FP INCONS 23
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.589
Average MCC ± 95% Confidence Intervals 0.541 ± 0.642
Sensitivity 0.570
Positive Predictive Value 0.626
Nr of predictions 4

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2. Individual counts for Fold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.