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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & MCFold [.zip] - may take several seconds...


Overview

Metric Multilign(seed) MCFold
MCC 0.589 > 0.586
Average MCC ± 95% Confidence Intervals 0.515 ± 1.207 < 0.587 ± 0.655
Sensitivity 0.549 < 0.592
Positive Predictive Value 0.650 > 0.600
Total TP 39 < 42
Total TN 2867 > 2857
Total FP 21 < 30
Total FP CONTRA 6 > 1
Total FP INCONS 15 < 27
Total FP COMP 0 < 2
Total FN 32 > 29
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and MCFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and MCFold).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 39
Total TN 2867
Total FP 21
Total FP CONTRA 6
Total FP INCONS 15
Total FP COMP 0
Total FN 32
Total Scores
MCC 0.589
Average MCC ± 95% Confidence Intervals 0.515 ± 1.207
Sensitivity 0.549
Positive Predictive Value 0.650
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 42
Total TN 2857
Total FP 30
Total FP CONTRA 1
Total FP INCONS 27
Total FP COMP 2
Total FN 29
Total Scores
MCC 0.586
Average MCC ± 95% Confidence Intervals 0.587 ± 0.655
Sensitivity 0.592
Positive Predictive Value 0.600
Nr of predictions 3

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.44 0.47 8 511 10 0 9 1 10
3RKF_A 0.89 0.88 0.91 21 843 3 0 2 1 3
3SD1_A 0.43 0.45 0.43 13 1503 17 1 16 0 16

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.