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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of ProbKnot - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & ProbKnot [.zip] - may take several seconds...


Overview

Metric Multilign(seed) ProbKnot
MCC 0.629 > 0.575
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654 > 0.524 ± 0.616
Sensitivity 0.580 > 0.570
Positive Predictive Value 0.699 > 0.600
Total TP 58 > 57
Total TN 4281 > 4269
Total FP 26 < 39
Total FP CONTRA 7 < 15
Total FP INCONS 18 < 23
Total FP COMP 1 = 1
Total FN 42 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and ProbKnot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and ProbKnot).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and ProbKnot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and ProbKnot).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP 57
Total TN 4269
Total FP 39
Total FP CONTRA 15
Total FP INCONS 23
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.575
Average MCC ± 95% Confidence Intervals 0.524 ± 0.616
Sensitivity 0.570
Positive Predictive Value 0.600
Nr of predictions 4

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.66 0.69 0.65 20 1502 11 6 5 0 9
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.