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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RDfolder [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RDfolder
MCC 0.629 > 0.444
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654 > 0.412 ± 0.615
Sensitivity 0.580 > 0.380
Positive Predictive Value 0.699 > 0.543
Total TP 58 > 38
Total TN 4281 < 4294
Total FP 26 < 33
Total FP CONTRA 7 = 7
Total FP INCONS 18 < 25
Total FP COMP 1 = 1
Total FN 42 < 62
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RDfolder).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 38
Total TN 4294
Total FP 33
Total FP CONTRA 7
Total FP INCONS 25
Total FP COMP 1
Total FN 62
Total Scores
MCC 0.444
Average MCC ± 95% Confidence Intervals 0.412 ± 0.615
Sensitivity 0.380
Positive Predictive Value 0.543
Nr of predictions 4

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 514 14 3 11 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.35 0.24 0.54 7 1520 6 1 5 0 22
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.