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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of Fold - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & Fold [.zip] - may take several seconds...


Overview

Metric NanoFolder Fold
MCC 0.427 > 0.366
Average MCC ± 95% Confidence Intervals 0.470 ± 0.376 > 0.339 ± 0.333
Sensitivity 0.519 > 0.385
Positive Predictive Value 0.365 > 0.364
Total TP 54 > 40
Total TN 8105 < 8143
Total FP 113 > 86
Total FP CONTRA 31 > 20
Total FP INCONS 63 > 50
Total FP COMP 19 > 16
Total FN 50 < 64
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and Fold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and Fold).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 54
Total TN 8105
Total FP 113
Total FP CONTRA 31
Total FP INCONS 63
Total FP COMP 19
Total FN 50
Total Scores
MCC 0.427
Average MCC ± 95% Confidence Intervals 0.470 ± 0.376
Sensitivity 0.519
Positive Predictive Value 0.365
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
3U4M_B - 0.77 0.91 0.67 20 1246 12 6 4 2 2
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Performance of Fold - scored lower in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP 40
Total TN 8143
Total FP 86
Total FP CONTRA 20
Total FP INCONS 50
Total FP COMP 16
Total FN 64
Total Scores
MCC 0.366
Average MCC ± 95% Confidence Intervals 0.339 ± 0.333
Sensitivity 0.385
Positive Predictive Value 0.364
Nr of predictions 5

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2. Individual counts for Fold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3U4M_B - 0.58 0.59 0.59 13 1254 9 2 7 0 9
4A1C_2 0.19 0.25 0.15 5 4482 43 11 18 14 15
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENC_A 0.36 0.33 0.42 5 484 8 0 7 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.