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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of RSpredict(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & RSpredict(seed) [.zip] - may take several seconds...


Overview

Metric NanoFolder RSpredict(seed)
MCC 0.336 > 0.179
Average MCC ± 95% Confidence Intervals 0.394 ± 0.460 > 0.180 ± 0.364
Sensitivity 0.415 > 0.110
Positive Predictive Value 0.288 < 0.310
Total TP 34 > 9
Total TN 6859 < 6948
Total FP 101 > 21
Total FP CONTRA 25 > 2
Total FP INCONS 59 > 18
Total FP COMP 17 > 1
Total FN 48 < 73
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and RSpredict(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and RSpredict(seed)).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 34
Total TN 6859
Total FP 101
Total FP CONTRA 25
Total FP INCONS 59
Total FP COMP 17
Total FN 48
Total Scores
MCC 0.336
Average MCC ± 95% Confidence Intervals 0.394 ± 0.460
Sensitivity 0.415
Positive Predictive Value 0.288
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 9
Total TN 6948
Total FP 21
Total FP CONTRA 2
Total FP INCONS 18
Total FP COMP 1
Total FN 73
Total Scores
MCC 0.179
Average MCC ± 95% Confidence Intervals 0.180 ± 0.364
Sensitivity 0.110
Positive Predictive Value 0.310
Nr of predictions 4

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
4A1C_2 0.00 0.00 0.00 0 4512 5 2 2 1 20
4AOB_A 0.42 0.21 0.86 6 1430 1 0 1 0 23
4ENC_A 0.34 0.20 0.60 3 491 2 0 2 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.