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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & Vsfold4 [.zip] - may take several seconds...


Overview

Metric NanoFolder Vsfold4
MCC 0.427 > 0.419
Average MCC ± 95% Confidence Intervals 0.470 ± 0.376 > 0.419 ± 0.361
Sensitivity 0.519 > 0.413
Positive Predictive Value 0.365 < 0.439
Total TP 54 > 43
Total TN 8105 < 8155
Total FP 113 > 68
Total FP CONTRA 31 > 10
Total FP INCONS 63 > 45
Total FP COMP 19 > 13
Total FN 50 < 61
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and Vsfold4).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and Vsfold4).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 54
Total TN 8105
Total FP 113
Total FP CONTRA 31
Total FP INCONS 63
Total FP COMP 19
Total FN 50
Total Scores
MCC 0.427
Average MCC ± 95% Confidence Intervals 0.470 ± 0.376
Sensitivity 0.519
Positive Predictive Value 0.365
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
3U4M_B - 0.77 0.91 0.67 20 1246 12 6 4 2 2
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 43
Total TN 8155
Total FP 68
Total FP CONTRA 10
Total FP INCONS 45
Total FP COMP 13
Total FN 61
Total Scores
MCC 0.419
Average MCC ± 95% Confidence Intervals 0.419 ± 0.361
Sensitivity 0.413
Positive Predictive Value 0.439
Nr of predictions 5

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.