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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & Vsfold5 [.zip] - may take several seconds...


Overview

Metric NanoFolder Vsfold5
MCC 0.427 > 0.379
Average MCC ± 95% Confidence Intervals 0.470 ± 0.376 > 0.395 ± 0.462
Sensitivity 0.519 > 0.394
Positive Predictive Value 0.365 < 0.380
Total TP 54 > 41
Total TN 8105 < 8145
Total FP 113 > 84
Total FP CONTRA 31 > 14
Total FP INCONS 63 > 53
Total FP COMP 19 > 17
Total FN 50 < 63
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and Vsfold5).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and Vsfold5).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 54
Total TN 8105
Total FP 113
Total FP CONTRA 31
Total FP INCONS 63
Total FP COMP 19
Total FN 50
Total Scores
MCC 0.427
Average MCC ± 95% Confidence Intervals 0.470 ± 0.376
Sensitivity 0.519
Positive Predictive Value 0.365
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
3U4M_B - 0.77 0.91 0.67 20 1246 12 6 4 2 2
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 41
Total TN 8145
Total FP 84
Total FP CONTRA 14
Total FP INCONS 53
Total FP COMP 17
Total FN 63
Total Scores
MCC 0.379
Average MCC ± 95% Confidence Intervals 0.395 ± 0.462
Sensitivity 0.394
Positive Predictive Value 0.380
Nr of predictions 5

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.