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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & MCFold [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) MCFold
MCC 0.465 > 0.371
Average MCC ± 95% Confidence Intervals 0.514 ± 0.581 > 0.434 ± 0.772
Sensitivity 0.420 = 0.420
Positive Predictive Value 0.525 > 0.339
Total TP 21 = 21
Total TN 5444 > 5422
Total FP 29 < 60
Total FP CONTRA 2 < 12
Total FP INCONS 17 < 29
Total FP COMP 10 < 19
Total FN 29 = 29
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MCFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MCFold).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 21
Total TN 5444
Total FP 29
Total FP CONTRA 2
Total FP INCONS 17
Total FP COMP 10
Total FN 29
Total Scores
MCC 0.465
Average MCC ± 95% Confidence Intervals 0.514 ± 0.581
Sensitivity 0.420
Positive Predictive Value 0.525
Nr of predictions 3

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 21
Total TN 5422
Total FP 60
Total FP CONTRA 12
Total FP INCONS 29
Total FP COMP 19
Total FN 29
Total Scores
MCC 0.371
Average MCC ± 95% Confidence Intervals 0.434 ± 0.772
Sensitivity 0.420
Positive Predictive Value 0.339
Nr of predictions 3

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.