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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) Multilign(20)
MCC 0.619 > 0.446
Average MCC ± 95% Confidence Intervals 0.603 ± 0.416 > 0.476 ± 0.369
Sensitivity 0.570 > 0.443
Positive Predictive Value 0.682 > 0.461
Total TP 45 > 35
Total TN 6855 > 6845
Total FP 33 < 50
Total FP CONTRA 2 < 13
Total FP INCONS 19 < 28
Total FP COMP 12 > 9
Total FN 34 < 44
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and Multilign(20)).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 45
Total TN 6855
Total FP 33
Total FP CONTRA 2
Total FP INCONS 19
Total FP COMP 12
Total FN 34
Total Scores
MCC 0.619
Average MCC ± 95% Confidence Intervals 0.603 ± 0.416
Sensitivity 0.570
Positive Predictive Value 0.682
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 35
Total TN 6845
Total FP 50
Total FP CONTRA 13
Total FP INCONS 28
Total FP COMP 9
Total FN 44
Total Scores
MCC 0.446
Average MCC ± 95% Confidence Intervals 0.476 ± 0.369
Sensitivity 0.443
Positive Predictive Value 0.461
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.