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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of CentroidAlifold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & CentroidAlifold(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) CentroidAlifold(20)
MCC 0.751 > 0.698
Average MCC ± 95% Confidence Intervals 0.717 ± 0.195 > 0.668 ± 0.379
Sensitivity 0.684 > 0.557
Positive Predictive Value 0.831 < 0.880
Total TP 54 > 44
Total TN 6856 < 6871
Total FP 26 > 10
Total FP CONTRA 3 = 3
Total FP INCONS 8 > 3
Total FP COMP 15 > 4
Total FN 25 < 35
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and CentroidAlifold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and CentroidAlifold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 54
Total TN 6856
Total FP 26
Total FP CONTRA 3
Total FP INCONS 8
Total FP COMP 15
Total FN 25
Total Scores
MCC 0.751
Average MCC ± 95% Confidence Intervals 0.717 ± 0.195
Sensitivity 0.684
Positive Predictive Value 0.831
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Performance of CentroidAlifold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 44
Total TN 6871
Total FP 10
Total FP CONTRA 3
Total FP INCONS 3
Total FP COMP 4
Total FN 35
Total Scores
MCC 0.698
Average MCC ± 95% Confidence Intervals 0.668 ± 0.379
Sensitivity 0.557
Positive Predictive Value 0.880
Nr of predictions 4

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.33 0.25 0.45 5 4505 8 3 3 2 15
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.