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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & CentroidHomfold‑LAST [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) CentroidHomfold‑LAST
MCC 0.695 > 0.558
Average MCC ± 95% Confidence Intervals 0.656 ± 0.215 > 0.554 ± 0.520
Sensitivity 0.619 > 0.495
Positive Predictive Value 0.789 > 0.640
Total TP 60 > 48
Total TN 7373 < 7374
Total FP 31 < 41
Total FP CONTRA 3 < 8
Total FP INCONS 13 < 19
Total FP COMP 15 > 14
Total FN 37 < 49
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and CentroidHomfold-LAST. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidHomfold‑LAST).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and CentroidHomfold-LAST. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidHomfold‑LAST).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 60
Total TN 7373
Total FP 31
Total FP CONTRA 3
Total FP INCONS 13
Total FP COMP 15
Total FN 37
Total Scores
MCC 0.695
Average MCC ± 95% Confidence Intervals 0.656 ± 0.215
Sensitivity 0.619
Positive Predictive Value 0.789
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 0 5 0 12
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 48
Total TN 7374
Total FP 41
Total FP CONTRA 8
Total FP INCONS 19
Total FP COMP 14
Total FN 49
Total Scores
MCC 0.558
Average MCC ± 95% Confidence Intervals 0.554 ± 0.520
Sensitivity 0.495
Positive Predictive Value 0.640
Nr of predictions 5

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 517 11 0 11 0 18
4A1C_2 0.24 0.25 0.24 5 4495 29 8 8 13 15
4AOB_A 0.85 0.72 1.00 21 1416 1 0 0 1 8
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.