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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of HotKnots - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & HotKnots [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) HotKnots
MCC 0.695 > 0.613
Average MCC ± 95% Confidence Intervals 0.656 ± 0.215 < 0.679 ± 0.409
Sensitivity 0.619 < 0.649
Positive Predictive Value 0.789 > 0.589
Total TP 60 < 63
Total TN 7373 > 7342
Total FP 31 < 59
Total FP CONTRA 3 < 17
Total FP INCONS 13 < 27
Total FP COMP 15 = 15
Total FN 37 > 34
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and HotKnots. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and HotKnots).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and HotKnots. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and HotKnots).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 60
Total TN 7373
Total FP 31
Total FP CONTRA 3
Total FP INCONS 13
Total FP COMP 15
Total FN 37
Total Scores
MCC 0.695
Average MCC ± 95% Confidence Intervals 0.656 ± 0.215
Sensitivity 0.619
Positive Predictive Value 0.789
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 0 5 0 12
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Performance of HotKnots - scored lower in this pairwise comparison

1. Total counts & total scores for HotKnots

Total Base Pair Counts
Total TP 63
Total TN 7342
Total FP 59
Total FP CONTRA 17
Total FP INCONS 27
Total FP COMP 15
Total FN 34
Total Scores
MCC 0.613
Average MCC ± 95% Confidence Intervals 0.679 ± 0.409
Sensitivity 0.649
Positive Predictive Value 0.589
Nr of predictions 5

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2. Individual counts for HotKnots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 5 0 5 0 7
4A1C_2 0.19 0.25 0.15 5 4483 42 12 16 14 15
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.