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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of IPknot - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & IPknot [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) IPknot
MCC 0.695 > 0.484
Average MCC ± 95% Confidence Intervals 0.656 ± 0.215 > 0.516 ± 0.285
Sensitivity 0.619 > 0.454
Positive Predictive Value 0.789 > 0.530
Total TP 60 > 44
Total TN 7373 > 7366
Total FP 31 < 48
Total FP CONTRA 3 < 12
Total FP INCONS 13 < 27
Total FP COMP 15 > 9
Total FN 37 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and IPknot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and IPknot).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and IPknot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and IPknot).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 60
Total TN 7373
Total FP 31
Total FP CONTRA 3
Total FP INCONS 13
Total FP COMP 15
Total FN 37
Total Scores
MCC 0.695
Average MCC ± 95% Confidence Intervals 0.656 ± 0.215
Sensitivity 0.619
Positive Predictive Value 0.789
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 0 5 0 12
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Performance of IPknot - scored lower in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP 44
Total TN 7366
Total FP 48
Total FP CONTRA 12
Total FP INCONS 27
Total FP COMP 9
Total FN 53
Total Scores
MCC 0.484
Average MCC ± 95% Confidence Intervals 0.516 ± 0.285
Sensitivity 0.454
Positive Predictive Value 0.530
Nr of predictions 5

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 1 4 0 12
4A1C_2 0.23 0.25 0.22 5 4493 26 8 10 8 15
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.59 0.53 0.67 8 484 4 0 4 0 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.