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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) NanoFolder
MCC 0.709 > 0.336
Average MCC ± 95% Confidence Intervals 0.666 ± 0.315 > 0.394 ± 0.460
Sensitivity 0.634 > 0.415
Positive Predictive Value 0.800 > 0.288
Total TP 52 > 34
Total TN 6912 > 6859
Total FP 26 < 101
Total FP CONTRA 2 < 25
Total FP INCONS 11 < 59
Total FP COMP 13 < 17
Total FN 30 < 48
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and NanoFolder).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 52
Total TN 6912
Total FP 26
Total FP CONTRA 2
Total FP INCONS 11
Total FP COMP 13
Total FN 30
Total Scores
MCC 0.709
Average MCC ± 95% Confidence Intervals 0.666 ± 0.315
Sensitivity 0.634
Positive Predictive Value 0.800
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 0 5 0 12
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 34
Total TN 6859
Total FP 101
Total FP CONTRA 25
Total FP INCONS 59
Total FP COMP 17
Total FN 48
Total Scores
MCC 0.336
Average MCC ± 95% Confidence Intervals 0.394 ± 0.460
Sensitivity 0.415
Positive Predictive Value 0.288
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.