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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Pknots - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Pknots [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Pknots
MCC 0.695 > 0.579
Average MCC ± 95% Confidence Intervals 0.656 ± 0.215 < 0.665 ± 0.465
Sensitivity 0.619 > 0.608
Positive Predictive Value 0.789 > 0.562
Total TP 60 > 59
Total TN 7373 > 7344
Total FP 31 < 65
Total FP CONTRA 3 < 15
Total FP INCONS 13 < 31
Total FP COMP 15 < 19
Total FN 37 < 38
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Pknots. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Pknots).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Pknots. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Pknots).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 60
Total TN 7373
Total FP 31
Total FP CONTRA 3
Total FP INCONS 13
Total FP COMP 15
Total FN 37
Total Scores
MCC 0.695
Average MCC ± 95% Confidence Intervals 0.656 ± 0.215
Sensitivity 0.619
Positive Predictive Value 0.789
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 0 5 0 12
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Performance of Pknots - scored lower in this pairwise comparison

1. Total counts & total scores for Pknots

Total Base Pair Counts
Total TP 59
Total TN 7344
Total FP 65
Total FP CONTRA 15
Total FP INCONS 31
Total FP COMP 19
Total FN 38
Total Scores
MCC 0.579
Average MCC ± 95% Confidence Intervals 0.665 ± 0.465
Sensitivity 0.608
Positive Predictive Value 0.562
Nr of predictions 5

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2. Individual counts for Pknots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.83 0.83 0.83 15 510 3 2 1 0 3
4A1C_2 0.33 0.40 0.29 8 4488 36 9 11 16 12
4AOB_A 0.19 0.21 0.21 6 1409 23 3 19 1 23
4ENB_A 1.00 1.00 1.00 15 457 2 0 0 2 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.