CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric PPfold(20) Carnac(20)
MCC 0.715 > 0.600
Average MCC ± 95% Confidence Intervals 0.682 ± 0.240 > 0.440 ± 0.395
Sensitivity 0.644 > 0.417
Positive Predictive Value 0.802 < 0.873
Total TP 85 > 55
Total TN 9214 < 9257
Total FP 27 > 10
Total FP CONTRA 3 > 2
Total FP INCONS 18 > 6
Total FP COMP 6 > 2
Total FN 47 < 77
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and Carnac(20)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 85
Total TN 9214
Total FP 27
Total FP CONTRA 3
Total FP INCONS 18
Total FP COMP 6
Total FN 47
Total Scores
MCC 0.715
Average MCC ± 95% Confidence Intervals 0.682 ± 0.240
Sensitivity 0.644
Positive Predictive Value 0.802
Nr of predictions 6

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.79 0.95 19 846 1 0 1 0 5
3SD1_A 0.81 0.76 0.88 22 1508 3 2 1 0 7
4A1C_2 0.27 0.25 0.29 5 4499 16 1 11 4 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 55
Total TN 9257
Total FP 10
Total FP CONTRA 2
Total FP INCONS 6
Total FP COMP 2
Total FN 77
Total Scores
MCC 0.600
Average MCC ± 95% Confidence Intervals 0.440 ± 0.395
Sensitivity 0.417
Positive Predictive Value 0.873
Nr of predictions 6

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.