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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & Cylofold [.zip] - may take several seconds...


Overview

Metric PPfold(20) Cylofold
MCC 0.797 > 0.756
Average MCC ± 95% Confidence Intervals 0.765 ± 0.147 < 0.801 ± 0.302
Sensitivity 0.714 < 0.723
Positive Predictive Value 0.899 > 0.802
Total TP 80 < 81
Total TN 4715 > 4703
Total FP 11 < 21
Total FP CONTRA 2 < 6
Total FP INCONS 7 < 14
Total FP COMP 2 > 1
Total FN 32 > 31
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and Cylofold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and Cylofold).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 80
Total TN 4715
Total FP 11
Total FP CONTRA 2
Total FP INCONS 7
Total FP COMP 2
Total FN 32
Total Scores
MCC 0.797
Average MCC ± 95% Confidence Intervals 0.765 ± 0.147
Sensitivity 0.714
Positive Predictive Value 0.899
Nr of predictions 5

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.79 0.95 19 846 1 0 1 0 5
3SD1_A 0.81 0.76 0.88 22 1508 3 2 1 0 7
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 81
Total TN 4703
Total FP 21
Total FP CONTRA 6
Total FP INCONS 14
Total FP COMP 1
Total FN 31
Total Scores
MCC 0.756
Average MCC ± 95% Confidence Intervals 0.801 ± 0.302
Sensitivity 0.723
Positive Predictive Value 0.802
Nr of predictions 5

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.