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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric PPfold(20) NanoFolder
MCC 0.632 > 0.285
Average MCC ± 95% Confidence Intervals 0.595 ± 0.757 > 0.346 ± 0.831
Sensitivity 0.578 > 0.359
Positive Predictive Value 0.698 > 0.240
Total TP 37 > 23
Total TN 6396 > 6353
Total FP 22 < 90
Total FP CONTRA 1 < 24
Total FP INCONS 15 < 49
Total FP COMP 6 < 17
Total FN 27 < 41
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and NanoFolder).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 37
Total TN 6396
Total FP 22
Total FP CONTRA 1
Total FP INCONS 15
Total FP COMP 6
Total FN 27
Total Scores
MCC 0.632
Average MCC ± 95% Confidence Intervals 0.595 ± 0.757
Sensitivity 0.578
Positive Predictive Value 0.698
Nr of predictions 3

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.27 0.25 0.29 5 4499 16 1 11 4 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 23
Total TN 6353
Total FP 90
Total FP CONTRA 24
Total FP INCONS 49
Total FP COMP 17
Total FN 41
Total Scores
MCC 0.285
Average MCC ± 95% Confidence Intervals 0.346 ± 0.831
Sensitivity 0.359
Positive Predictive Value 0.240
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.