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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of ProbKnot - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & ProbKnot [.zip] - may take several seconds...


Overview

Metric PPfold(20) ProbKnot
MCC 0.715 > 0.577
Average MCC ± 95% Confidence Intervals 0.682 ± 0.240 > 0.606 ± 0.261
Sensitivity 0.644 > 0.614
Positive Predictive Value 0.802 > 0.555
Total TP 85 > 81
Total TN 9214 > 9174
Total FP 27 < 82
Total FP CONTRA 3 < 26
Total FP INCONS 18 < 39
Total FP COMP 6 < 17
Total FN 47 < 51
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and ProbKnot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and ProbKnot).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and ProbKnot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and ProbKnot).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 85
Total TN 9214
Total FP 27
Total FP CONTRA 3
Total FP INCONS 18
Total FP COMP 6
Total FN 47
Total Scores
MCC 0.715
Average MCC ± 95% Confidence Intervals 0.682 ± 0.240
Sensitivity 0.644
Positive Predictive Value 0.802
Nr of predictions 6

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.79 0.95 19 846 1 0 1 0 5
3SD1_A 0.81 0.76 0.88 22 1508 3 2 1 0 7
4A1C_2 0.27 0.25 0.29 5 4499 16 1 11 4 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP 81
Total TN 9174
Total FP 82
Total FP CONTRA 26
Total FP INCONS 39
Total FP COMP 17
Total FN 51
Total Scores
MCC 0.577
Average MCC ± 95% Confidence Intervals 0.606 ± 0.261
Sensitivity 0.614
Positive Predictive Value 0.555
Nr of predictions 6

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.66 0.69 0.65 20 1502 11 6 5 0 9
4A1C_2 0.17 0.25 0.13 5 4477 49 13 21 15 15
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 0.81 0.73 0.92 11 460 1 1 0 0 4
4ENC_A 0.52 0.53 0.53 8 481 8 0 7 1 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.