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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & RDfolder [.zip] - may take several seconds...


Overview

Metric PPfold(20) RDfolder
MCC 0.797 > 0.533
Average MCC ± 95% Confidence Intervals 0.765 ± 0.147 > 0.527 ± 0.274
Sensitivity 0.714 > 0.446
Positive Predictive Value 0.899 > 0.658
Total TP 80 > 50
Total TN 4715 < 4728
Total FP 11 < 27
Total FP CONTRA 2 < 4
Total FP INCONS 7 < 22
Total FP COMP 2 > 1
Total FN 32 < 62
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and RDfolder).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 80
Total TN 4715
Total FP 11
Total FP CONTRA 2
Total FP INCONS 7
Total FP COMP 2
Total FN 32
Total Scores
MCC 0.797
Average MCC ± 95% Confidence Intervals 0.765 ± 0.147
Sensitivity 0.714
Positive Predictive Value 0.899
Nr of predictions 5

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.79 0.95 19 846 1 0 1 0 5
3SD1_A 0.81 0.76 0.88 22 1508 3 2 1 0 7
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 50
Total TN 4728
Total FP 27
Total FP CONTRA 4
Total FP INCONS 22
Total FP COMP 1
Total FN 62
Total Scores
MCC 0.533
Average MCC ± 95% Confidence Intervals 0.527 ± 0.274
Sensitivity 0.446
Positive Predictive Value 0.658
Nr of predictions 5

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.35 0.24 0.54 7 1520 6 1 5 0 22
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 0.48 0.40 0.60 6 462 4 0 4 0 9
4ENC_A 0.48 0.40 0.60 6 486 4 0 4 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.