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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of RNASLOpt - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & RNASLOpt [.zip] - may take several seconds...


Overview

Metric PPfold(20) RNASLOpt
MCC 0.630 > 0.459
Average MCC ± 95% Confidence Intervals 0.604 ± 0.397 > 0.549 ± 0.451
Sensitivity 0.557 > 0.456
Positive Predictive Value 0.721 > 0.474
Total TP 44 > 36
Total TN 6860 > 6845
Total FP 23 < 49
Total FP CONTRA 1 < 17
Total FP INCONS 16 < 23
Total FP COMP 6 < 9
Total FN 35 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and RNASLOpt).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and RNASLOpt).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 44
Total TN 6860
Total FP 23
Total FP CONTRA 1
Total FP INCONS 16
Total FP COMP 6
Total FN 35
Total Scores
MCC 0.630
Average MCC ± 95% Confidence Intervals 0.604 ± 0.397
Sensitivity 0.557
Positive Predictive Value 0.721
Nr of predictions 4

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.27 0.25 0.29 5 4499 16 1 11 4 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 36
Total TN 6845
Total FP 49
Total FP CONTRA 17
Total FP INCONS 23
Total FP COMP 9
Total FN 43
Total Scores
MCC 0.459
Average MCC ± 95% Confidence Intervals 0.549 ± 0.451
Sensitivity 0.456
Positive Predictive Value 0.474
Nr of predictions 4

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.30 0.40 0.24 8 4482 35 13 13 9 12
4AOB_A 0.31 0.28 0.38 8 1416 13 3 10 0 21
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.