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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of RNAalifold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & RNAalifold(seed) [.zip] - may take several seconds...


Overview

Metric PPfold(20) RNAalifold(seed)
MCC 0.715 > 0.701
Average MCC ± 95% Confidence Intervals 0.682 ± 0.240 > 0.674 ± 0.125
Sensitivity 0.644 > 0.538
Positive Predictive Value 0.802 < 0.922
Total TP 85 > 71
Total TN 9214 < 9243
Total FP 27 > 10
Total FP CONTRA 3 = 3
Total FP INCONS 18 > 3
Total FP COMP 6 > 4
Total FN 47 < 61
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and RNAalifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and RNAalifold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and RNAalifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and RNAalifold(seed)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 85
Total TN 9214
Total FP 27
Total FP CONTRA 3
Total FP INCONS 18
Total FP COMP 6
Total FN 47
Total Scores
MCC 0.715
Average MCC ± 95% Confidence Intervals 0.682 ± 0.240
Sensitivity 0.644
Positive Predictive Value 0.802
Nr of predictions 6

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.79 0.95 19 846 1 0 1 0 5
3SD1_A 0.81 0.76 0.88 22 1508 3 2 1 0 7
4A1C_2 0.27 0.25 0.29 5 4499 16 1 11 4 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of RNAalifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 71
Total TN 9243
Total FP 10
Total FP CONTRA 3
Total FP INCONS 3
Total FP COMP 4
Total FN 61
Total Scores
MCC 0.701
Average MCC ± 95% Confidence Intervals 0.674 ± 0.125
Sensitivity 0.538
Positive Predictive Value 0.922
Nr of predictions 6

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.74 0.67 0.84 16 847 3 1 2 0 8
3SD1_A 0.70 0.59 0.85 17 1513 3 2 1 0 12
4A1C_2 0.50 0.25 1.00 5 4511 2 0 0 2 15
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.