CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of RNAwolf - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & RNAwolf [.zip] - may take several seconds...


Overview

Metric PPfold(20) RNAwolf
MCC 0.715 > 0.442
Average MCC ± 95% Confidence Intervals 0.682 ± 0.240 > 0.439 ± 0.284
Sensitivity 0.644 > 0.439
Positive Predictive Value 0.802 > 0.460
Total TP 85 > 58
Total TN 9214 > 9194
Total FP 27 < 82
Total FP CONTRA 3 < 17
Total FP INCONS 18 < 51
Total FP COMP 6 < 14
Total FN 47 < 74
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and RNAwolf).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and RNAwolf).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 85
Total TN 9214
Total FP 27
Total FP CONTRA 3
Total FP INCONS 18
Total FP COMP 6
Total FN 47
Total Scores
MCC 0.715
Average MCC ± 95% Confidence Intervals 0.682 ± 0.240
Sensitivity 0.644
Positive Predictive Value 0.802
Nr of predictions 6

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.79 0.95 19 846 1 0 1 0 5
3SD1_A 0.81 0.76 0.88 22 1508 3 2 1 0 7
4A1C_2 0.27 0.25 0.29 5 4499 16 1 11 4 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP 58
Total TN 9194
Total FP 82
Total FP CONTRA 17
Total FP INCONS 51
Total FP COMP 14
Total FN 74
Total Scores
MCC 0.442
Average MCC ± 95% Confidence Intervals 0.439 ± 0.284
Sensitivity 0.439
Positive Predictive Value 0.460
Nr of predictions 6

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.89 0.83 0.95 20 845 1 0 1 0 4
3SD1_A 0.58 0.59 0.59 17 1504 12 2 10 0 12
4A1C_2 0.12 0.15 0.10 3 4487 38 12 14 12 17
4AOB_A 0.26 0.24 0.30 7 1414 17 2 14 1 22
4ENB_A 0.45 0.40 0.55 6 461 5 1 4 0 9
4ENC_A 0.34 0.33 0.38 5 483 9 0 8 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.