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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PknotsRG - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PknotsRG & Multilign(20) [.zip] - may take several seconds...


Overview

Metric PknotsRG Multilign(20)
MCC 0.675 > 0.581
Average MCC ± 95% Confidence Intervals 0.732 ± 0.325 > 0.583 ± 0.267
Sensitivity 0.705 > 0.576
Positive Predictive Value 0.655 > 0.598
Total TP 93 > 76
Total TN 9178 < 9193
Total FP 62 > 60
Total FP CONTRA 20 > 17
Total FP INCONS 29 < 34
Total FP COMP 13 > 9
Total FN 39 < 56
P-value 0.0

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Performance plots


  1. Comparison of performance of PknotsRG and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PknotsRG and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PknotsRG and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PknotsRG and Multilign(20)).

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Performance of PknotsRG - scored higher in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP 93
Total TN 9178
Total FP 62
Total FP CONTRA 20
Total FP INCONS 29
Total FP COMP 13
Total FN 39
Total Scores
MCC 0.675
Average MCC ± 95% Confidence Intervals 0.732 ± 0.325
Sensitivity 0.705
Positive Predictive Value 0.655
Nr of predictions 6

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
4A1C_2 0.18 0.25 0.14 5 4480 43 11 20 12 15
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 76
Total TN 9193
Total FP 60
Total FP CONTRA 17
Total FP INCONS 34
Total FP COMP 9
Total FN 56
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.583 ± 0.267
Sensitivity 0.576
Positive Predictive Value 0.598
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.