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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PknotsRG - scored higher in this pairwise comparison

  4. Performance of TurboFold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PknotsRG & TurboFold(20) [.zip] - may take several seconds...


Overview

Metric PknotsRG TurboFold(20)
MCC 0.675 > 0.653
Average MCC ± 95% Confidence Intervals 0.732 ± 0.325 > 0.668 ± 0.244
Sensitivity 0.705 > 0.606
Positive Predictive Value 0.655 < 0.714
Total TP 93 > 80
Total TN 9178 < 9208
Total FP 62 > 42
Total FP CONTRA 20 > 11
Total FP INCONS 29 > 21
Total FP COMP 13 > 10
Total FN 39 < 52
P-value 0.0

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Performance plots


  1. Comparison of performance of PknotsRG and TurboFold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PknotsRG and TurboFold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PknotsRG and TurboFold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PknotsRG and TurboFold(20)).

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Performance of PknotsRG - scored higher in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP 93
Total TN 9178
Total FP 62
Total FP CONTRA 20
Total FP INCONS 29
Total FP COMP 13
Total FN 39
Total Scores
MCC 0.675
Average MCC ± 95% Confidence Intervals 0.732 ± 0.325
Sensitivity 0.705
Positive Predictive Value 0.655
Nr of predictions 6

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
4A1C_2 0.18 0.25 0.14 5 4480 43 11 20 12 15
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of TurboFold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 80
Total TN 9208
Total FP 42
Total FP CONTRA 11
Total FP INCONS 21
Total FP COMP 10
Total FN 52
Total Scores
MCC 0.653
Average MCC ± 95% Confidence Intervals 0.668 ± 0.244
Sensitivity 0.606
Positive Predictive Value 0.714
Nr of predictions 6

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.