CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASLOpt - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASLOpt & Carnac(20) [.zip] - may take several seconds...


Overview

Metric RNASLOpt Carnac(20)
MCC 0.459 > 0.416
Average MCC ± 95% Confidence Intervals 0.549 ± 0.451 > 0.253 ± 0.477
Sensitivity 0.456 > 0.241
Positive Predictive Value 0.474 < 0.731
Total TP 36 > 19
Total TN 6845 < 6895
Total FP 49 > 9
Total FP CONTRA 17 > 2
Total FP INCONS 23 > 5
Total FP COMP 9 > 2
Total FN 43 < 60
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASLOpt and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and Carnac(20)).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 36
Total TN 6845
Total FP 49
Total FP CONTRA 17
Total FP INCONS 23
Total FP COMP 9
Total FN 43
Total Scores
MCC 0.459
Average MCC ± 95% Confidence Intervals 0.549 ± 0.451
Sensitivity 0.456
Positive Predictive Value 0.474
Nr of predictions 4

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.30 0.40 0.24 8 4482 35 13 13 9 12
4AOB_A 0.31 0.28 0.38 8 1416 13 3 10 0 21
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 19
Total TN 6895
Total FP 9
Total FP CONTRA 2
Total FP INCONS 5
Total FP COMP 2
Total FN 60
Total Scores
MCC 0.416
Average MCC ± 95% Confidence Intervals 0.253 ± 0.477
Sensitivity 0.241
Positive Predictive Value 0.731
Nr of predictions 4

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.