CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASLOpt - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASLOpt & MCFold [.zip] - may take several seconds...


Overview

Metric RNASLOpt MCFold
MCC 0.483 > 0.436
Average MCC ± 95% Confidence Intervals 0.512 ± 0.256 > 0.437 ± 0.285
Sensitivity 0.485 > 0.475
Positive Predictive Value 0.495 > 0.414
Total TP 49 > 48
Total TN 7600 > 7583
Total FP 60 < 93
Total FP CONTRA 20 > 14
Total FP INCONS 30 < 54
Total FP COMP 10 < 25
Total FN 52 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASLOpt and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and MCFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and MCFold).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 49
Total TN 7600
Total FP 60
Total FP CONTRA 20
Total FP INCONS 30
Total FP COMP 10
Total FN 52
Total Scores
MCC 0.483
Average MCC ± 95% Confidence Intervals 0.512 ± 0.256
Sensitivity 0.485
Positive Predictive Value 0.495
Nr of predictions 6

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.48 0.39 0.64 7 517 4 0 4 0 11
3J0L_a - 0.21 0.18 0.29 2 404 6 3 2 1 9
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
4A1C_2 0.30 0.40 0.24 8 4482 35 13 13 9 12
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 48
Total TN 7583
Total FP 93
Total FP CONTRA 14
Total FP INCONS 54
Total FP COMP 25
Total FN 53
Total Scores
MCC 0.436
Average MCC ± 95% Confidence Intervals 0.437 ± 0.285
Sensitivity 0.475
Positive Predictive Value 0.414
Nr of predictions 6

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.44 0.47 8 511 10 0 9 1 10
3J0L_a - 0.14 0.18 0.15 2 398 13 1 10 2 9
3U4M_B - 0.74 0.77 0.71 17 1252 10 1 6 3 5
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.