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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASLOpt - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASLOpt & Multilign(20) [.zip] - may take several seconds...


Overview

Metric RNASLOpt Multilign(20)
MCC 0.459 > 0.446
Average MCC ± 95% Confidence Intervals 0.549 ± 0.451 > 0.476 ± 0.369
Sensitivity 0.456 > 0.443
Positive Predictive Value 0.474 > 0.461
Total TP 36 > 35
Total TN 6845 = 6845
Total FP 49 < 50
Total FP CONTRA 17 > 13
Total FP INCONS 23 < 28
Total FP COMP 9 = 9
Total FN 43 < 44
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASLOpt and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and Multilign(20)).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 36
Total TN 6845
Total FP 49
Total FP CONTRA 17
Total FP INCONS 23
Total FP COMP 9
Total FN 43
Total Scores
MCC 0.459
Average MCC ± 95% Confidence Intervals 0.549 ± 0.451
Sensitivity 0.456
Positive Predictive Value 0.474
Nr of predictions 4

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.30 0.40 0.24 8 4482 35 13 13 9 12
4AOB_A 0.31 0.28 0.38 8 1416 13 3 10 0 21
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 35
Total TN 6845
Total FP 50
Total FP CONTRA 13
Total FP INCONS 28
Total FP COMP 9
Total FN 44
Total Scores
MCC 0.446
Average MCC ± 95% Confidence Intervals 0.476 ± 0.369
Sensitivity 0.443
Positive Predictive Value 0.461
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.