CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASLOpt - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASLOpt & RDfolder [.zip] - may take several seconds...


Overview

Metric RNASLOpt RDfolder
MCC 0.499 > 0.299
Average MCC ± 95% Confidence Intervals 0.518 ± 0.336 > 0.265 ± 0.328
Sensitivity 0.420 > 0.261
Positive Predictive Value 0.617 > 0.377
Total TP 37 > 23
Total TN 3284 > 3283
Total FP 24 < 39
Total FP CONTRA 7 < 9
Total FP INCONS 16 < 29
Total FP COMP 1 = 1
Total FN 51 < 65
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASLOpt and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and RDfolder).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 37
Total TN 3284
Total FP 24
Total FP CONTRA 7
Total FP INCONS 16
Total FP COMP 1
Total FN 51
Total Scores
MCC 0.499
Average MCC ± 95% Confidence Intervals 0.518 ± 0.336
Sensitivity 0.420
Positive Predictive Value 0.617
Nr of predictions 5

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.48 0.39 0.64 7 517 4 0 4 0 11
3J0L_a - 0.21 0.18 0.29 2 404 6 3 2 1 9
4AOB_A 0.31 0.28 0.38 8 1416 13 3 10 0 21
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 23
Total TN 3283
Total FP 39
Total FP CONTRA 9
Total FP INCONS 29
Total FP COMP 1
Total FN 65
Total Scores
MCC 0.299
Average MCC ± 95% Confidence Intervals 0.265 ± 0.328
Sensitivity 0.261
Positive Predictive Value 0.377
Nr of predictions 5

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 514 14 3 11 0 18
3J0L_a - -0.02 0.00 0.00 0 407 4 3 1 0 11
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 0.48 0.40 0.60 6 462 4 0 4 0 9
4ENC_A 0.48 0.40 0.60 6 486 4 0 4 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.