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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric RNASampler(20) Multilign(20)
MCC 0.693 > 0.581
Average MCC ± 95% Confidence Intervals 0.698 ± 0.253 > 0.583 ± 0.267
Sensitivity 0.606 > 0.576
Positive Predictive Value 0.800 > 0.598
Total TP 80 > 76
Total TN 9220 > 9193
Total FP 35 < 60
Total FP CONTRA 3 < 17
Total FP INCONS 17 < 34
Total FP COMP 15 > 9
Total FN 52 < 56
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(20) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Multilign(20)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 80
Total TN 9220
Total FP 35
Total FP CONTRA 3
Total FP INCONS 17
Total FP COMP 15
Total FN 52
Total Scores
MCC 0.693
Average MCC ± 95% Confidence Intervals 0.698 ± 0.253
Sensitivity 0.606
Positive Predictive Value 0.800
Nr of predictions 6

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.81 0.69 0.95 20 1512 1 0 1 0 9
4A1C_2 0.24 0.25 0.24 5 4495 30 3 13 14 15
4AOB_A 0.70 0.59 0.85 17 1417 4 0 3 1 12
4ENB_A 0.68 0.47 1.00 7 465 0 0 0 0 8
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 76
Total TN 9193
Total FP 60
Total FP CONTRA 17
Total FP INCONS 34
Total FP COMP 9
Total FN 56
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.583 ± 0.267
Sensitivity 0.576
Positive Predictive Value 0.598
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.