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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(seed) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric RNAalifold(seed) Multilign(seed)
MCC 0.629 > 0.629
Average MCC ± 95% Confidence Intervals 0.566 ± 0.638 < 0.569 ± 0.654
Sensitivity 0.540 < 0.580
Positive Predictive Value 0.750 > 0.699
Total TP 54 < 58
Total TN 4292 > 4281
Total FP 20 < 26
Total FP CONTRA 3 < 7
Total FP INCONS 15 < 18
Total FP COMP 2 > 1
Total FN 46 > 42
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(seed) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and Multilign(seed)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 54
Total TN 4292
Total FP 20
Total FP CONTRA 3
Total FP INCONS 15
Total FP COMP 2
Total FN 46
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.566 ± 0.638
Sensitivity 0.540
Positive Predictive Value 0.750
Nr of predictions 4

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 0 12 0 18
3RKF_A 0.74 0.67 0.84 16 847 3 1 2 0 8
3SD1_A 0.70 0.59 0.85 17 1513 3 2 1 0 12
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.