CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAfold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAfold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric RNAfold Multilign(seed)
MCC 0.728 > 0.629
Average MCC ± 95% Confidence Intervals 0.729 ± 0.225 > 0.569 ± 0.654
Sensitivity 0.700 > 0.580
Positive Predictive Value 0.769 > 0.699
Total TP 70 > 58
Total TN 4273 < 4281
Total FP 22 < 26
Total FP CONTRA 8 > 7
Total FP INCONS 13 < 18
Total FP COMP 1 = 1
Total FN 30 < 42
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAfold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAfold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAfold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAfold and Multilign(seed)).

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Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 70
Total TN 4273
Total FP 22
Total FP CONTRA 8
Total FP INCONS 13
Total FP COMP 1
Total FN 30
Total Scores
MCC 0.728
Average MCC ± 95% Confidence Intervals 0.729 ± 0.225
Sensitivity 0.700
Positive Predictive Value 0.769
Nr of predictions 4

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 5 0 5 0 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.77 0.76 0.79 22 1505 6 4 2 0 7
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.