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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAshapes - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAshapes & Multilign(20) [.zip] - may take several seconds...


Overview

Metric RNAshapes Multilign(20)
MCC 0.608 > 0.581
Average MCC ± 95% Confidence Intervals 0.616 ± 0.298 > 0.583 ± 0.267
Sensitivity 0.606 > 0.576
Positive Predictive Value 0.620 > 0.598
Total TP 80 > 76
Total TN 9191 < 9193
Total FP 67 > 60
Total FP CONTRA 19 > 17
Total FP INCONS 30 < 34
Total FP COMP 18 > 9
Total FN 52 < 56
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAshapes and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and Multilign(20)).

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Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP 80
Total TN 9191
Total FP 67
Total FP CONTRA 19
Total FP INCONS 30
Total FP COMP 18
Total FN 52
Total Scores
MCC 0.608
Average MCC ± 95% Confidence Intervals 0.616 ± 0.298
Sensitivity 0.606
Positive Predictive Value 0.620
Nr of predictions 6

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.77 0.76 0.79 22 1505 6 4 2 0 7
4A1C_2 0.19 0.25 0.16 5 4484 41 11 16 14 15
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.37 0.33 0.45 5 485 7 0 6 1 10

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 76
Total TN 9193
Total FP 60
Total FP CONTRA 17
Total FP INCONS 34
Total FP COMP 9
Total FN 56
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.583 ± 0.267
Sensitivity 0.576
Positive Predictive Value 0.598
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.