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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAsubopt - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAsubopt & Multilign(20) [.zip] - may take several seconds...


Overview

Metric RNAsubopt Multilign(20)
MCC 0.596 > 0.581
Average MCC ± 95% Confidence Intervals 0.610 ± 0.301 > 0.583 ± 0.267
Sensitivity 0.606 > 0.576
Positive Predictive Value 0.597 < 0.598
Total TP 80 > 76
Total TN 9186 < 9193
Total FP 70 > 60
Total FP CONTRA 21 > 17
Total FP INCONS 33 < 34
Total FP COMP 16 > 9
Total FN 52 < 56
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAsubopt and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Multilign(20)).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 80
Total TN 9186
Total FP 70
Total FP CONTRA 21
Total FP INCONS 33
Total FP COMP 16
Total FN 52
Total Scores
MCC 0.596
Average MCC ± 95% Confidence Intervals 0.610 ± 0.301
Sensitivity 0.606
Positive Predictive Value 0.597
Nr of predictions 6

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
4A1C_2 0.18 0.25 0.14 5 4481 43 13 17 13 15
4AOB_A 0.62 0.62 0.64 18 1409 11 4 6 1 11
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.36 0.33 0.42 5 484 7 0 7 0 10

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 76
Total TN 9193
Total FP 60
Total FP CONTRA 17
Total FP INCONS 34
Total FP COMP 9
Total FN 56
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.583 ± 0.267
Sensitivity 0.576
Positive Predictive Value 0.598
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.