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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric RSpredict(20) NanoFolder
MCC 0.316 > 0.285
Average MCC ± 95% Confidence Intervals 0.360 ± 0.330 > 0.346 ± 0.831
Sensitivity 0.281 < 0.359
Positive Predictive Value 0.367 > 0.240
Total TP 18 < 23
Total TN 6400 > 6353
Total FP 38 < 90
Total FP CONTRA 13 < 24
Total FP INCONS 18 < 49
Total FP COMP 7 < 17
Total FN 46 > 41
P-value 0.0

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Performance plots


  1. Comparison of performance of RSpredict(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and NanoFolder).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 18
Total TN 6400
Total FP 38
Total FP CONTRA 13
Total FP INCONS 18
Total FP COMP 7
Total FN 46
Total Scores
MCC 0.316
Average MCC ± 95% Confidence Intervals 0.360 ± 0.330
Sensitivity 0.281
Positive Predictive Value 0.367
Nr of predictions 3

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 23
Total TN 6353
Total FP 90
Total FP CONTRA 24
Total FP INCONS 49
Total FP COMP 17
Total FN 41
Total Scores
MCC 0.285
Average MCC ± 95% Confidence Intervals 0.346 ± 0.831
Sensitivity 0.359
Positive Predictive Value 0.240
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.