CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(20) - scored higher in this pairwise comparison

  4. Performance of RNAwolf - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(20) & RNAwolf [.zip] - may take several seconds...


Overview

Metric RSpredict(20) RNAwolf
MCC 0.573 > 0.442
Average MCC ± 95% Confidence Intervals 0.558 ± 0.276 > 0.439 ± 0.284
Sensitivity 0.530 > 0.439
Positive Predictive Value 0.631 > 0.460
Total TP 70 > 58
Total TN 9209 > 9194
Total FP 48 < 82
Total FP CONTRA 19 > 17
Total FP INCONS 22 < 51
Total FP COMP 7 < 14
Total FN 62 < 74
P-value 0.0

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Performance plots


  1. Comparison of performance of RSpredict(20) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and RNAwolf).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and RNAwolf).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 70
Total TN 9209
Total FP 48
Total FP CONTRA 19
Total FP INCONS 22
Total FP COMP 7
Total FN 62
Total Scores
MCC 0.573
Average MCC ± 95% Confidence Intervals 0.558 ± 0.276
Sensitivity 0.530
Positive Predictive Value 0.631
Nr of predictions 6

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 1 0 0 3
3SD1_A 0.82 0.86 0.78 25 1501 7 5 2 0 4
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP 58
Total TN 9194
Total FP 82
Total FP CONTRA 17
Total FP INCONS 51
Total FP COMP 14
Total FN 74
Total Scores
MCC 0.442
Average MCC ± 95% Confidence Intervals 0.439 ± 0.284
Sensitivity 0.439
Positive Predictive Value 0.460
Nr of predictions 6

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.89 0.83 0.95 20 845 1 0 1 0 4
3SD1_A 0.58 0.59 0.59 17 1504 12 2 10 0 12
4A1C_2 0.12 0.15 0.10 3 4487 38 12 14 12 17
4AOB_A 0.26 0.24 0.30 7 1414 17 2 14 1 22
4ENB_A 0.45 0.40 0.55 6 461 5 1 4 0 9
4ENC_A 0.34 0.33 0.38 5 483 9 0 8 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.