CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(seed) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric RSpredict(seed) Mastr(seed)
MCC 0.324 > 0.000
Average MCC ± 95% Confidence Intervals 0.291 ± 0.143 > 0.000 ± 0.000
Sensitivity 0.177 > 0.000
Positive Predictive Value 0.600 > 0.000
Total TP 102 > 0
Total TN 77545 < 77715
Total FP 78 > 0
Total FP CONTRA 17 > 0
Total FP INCONS 51 > 0
Total FP COMP 10 > 0
Total FN 473 < 575
P-value 3.05041766982e-08

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Performance plots


  1. Comparison of performance of RSpredict(seed) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(seed) and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RSpredict(seed) and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(seed) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(seed) and Mastr(seed)).

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Performance of RSpredict(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 102
Total TN 77545
Total FP 78
Total FP CONTRA 17
Total FP INCONS 51
Total FP COMP 10
Total FN 473
Total Scores
MCC 0.324
Average MCC ± 95% Confidence Intervals 0.291 ± 0.143
Sensitivity 0.177
Positive Predictive Value 0.600
Nr of predictions 19

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2ZZN_D 0.38 0.18 0.80 4 979 1 1 0 0 18
3A2K_C -0.01 0.00 0.00 0 1106 2 0 2 0 22
3A3A_A 0.53 0.37 0.79 11 1486 3 0 3 0 19
3GX2_A 0.42 0.21 0.86 6 1442 1 0 1 0 22
3IVN_B 0.81 0.70 0.94 16 886 1 1 0 0 7
3IYQ_A 0.16 0.10 0.26 5 22421 21 10 4 7 46
3IZ4_A 0.26 0.11 0.63 10 25520 7 2 4 1 85
3JYV_7 -0.01 0.00 0.00 0 1108 4 0 3 1 20
3LA5_A 0.82 0.68 1.00 17 937 0 0 0 0 8
3NPB_A -0.01 0.00 0.00 0 2274 4 0 4 0 37
3O58_3 0.28 0.14 0.60 3 4759 2 0 2 0 19
3PDR_A 0.00 0.00 0.00 0 4832 8 0 8 0 50
3RKF_A 0.84 0.75 0.95 18 847 1 1 0 0 6
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
4A1C_2 0.00 0.00 0.00 0 4512 5 2 2 1 20
4AOB_A 0.42 0.21 0.86 6 1430 1 0 1 0 23
4ENB_A 0.34 0.20 0.60 3 467 2 0 2 0 12
4ENC_A 0.34 0.20 0.60 3 491 2 0 2 0 12

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 77715
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 575
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 19

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.00 0.00 0.00 0 528 0 0 0 0 18
2ZZN_D 0.00 0.00 0.00 0 984 0 0 0 0 22
3A2K_C 0.00 0.00 0.00 0 1108 0 0 0 0 22
3A3A_A 0.00 0.00 0.00 0 1500 0 0 0 0 30
3GX2_A 0.00 0.00 0.00 0 1449 0 0 0 0 28
3IVN_B 0.00 0.00 0.00 0 903 0 0 0 0 23
3IYQ_A 0.00 0.00 0.00 0 22440 0 0 0 0 51
3IZ4_A 0.00 0.00 0.00 0 25536 0 0 0 0 95
3JYV_7 0.00 0.00 0.00 0 1111 0 0 0 0 20
3LA5_A 0.00 0.00 0.00 0 954 0 0 0 0 25
3NPB_A 0.00 0.00 0.00 0 2278 0 0 0 0 37
3O58_3 0.00 0.00 0.00 0 4764 0 0 0 0 22
3PDR_A 0.00 0.00 0.00 0 4840 0 0 0 0 50
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.