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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Sfold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Sfold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Sfold Multilign(seed)
MCC 0.703 > 0.629
Average MCC ± 95% Confidence Intervals 0.687 ± 0.313 > 0.569 ± 0.654
Sensitivity 0.650 > 0.580
Positive Predictive Value 0.774 > 0.699
Total TP 65 > 58
Total TN 4280 < 4281
Total FP 20 < 26
Total FP CONTRA 6 < 7
Total FP INCONS 13 < 18
Total FP COMP 1 = 1
Total FN 35 < 42
P-value 0.0

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Performance plots


  1. Comparison of performance of Sfold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Sfold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Sfold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Sfold and Multilign(seed)).

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Performance of Sfold - scored higher in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP 65
Total TN 4280
Total FP 20
Total FP CONTRA 6
Total FP INCONS 13
Total FP COMP 1
Total FN 35
Total Scores
MCC 0.703
Average MCC ± 95% Confidence Intervals 0.687 ± 0.313
Sensitivity 0.650
Positive Predictive Value 0.774
Nr of predictions 4

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.46 0.39 0.58 7 516 5 0 5 0 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.78 0.72 0.84 21 1508 4 2 2 0 8
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.