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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Afold [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Afold
MCC 0.604 > 0.577
Average MCC ± 95% Confidence Intervals 0.635 ± 0.900 < 0.639 ± 0.972
Sensitivity 0.576 < 0.610
Positive Predictive Value 0.642 > 0.554
Total TP 34 < 36
Total TN 5801 > 5789
Total FP 28 < 46
Total FP CONTRA 6 < 11
Total FP INCONS 13 < 18
Total FP COMP 9 < 17
Total FN 25 > 23
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Afold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Afold).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 34
Total TN 5801
Total FP 28
Total FP CONTRA 6
Total FP INCONS 13
Total FP COMP 9
Total FN 25
Total Scores
MCC 0.604
Average MCC ± 95% Confidence Intervals 0.635 ± 0.900
Sensitivity 0.576
Positive Predictive Value 0.642
Nr of predictions 3

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 36
Total TN 5789
Total FP 46
Total FP CONTRA 11
Total FP INCONS 18
Total FP COMP 17
Total FN 23
Total Scores
MCC 0.577
Average MCC ± 95% Confidence Intervals 0.639 ± 0.972
Sensitivity 0.610
Positive Predictive Value 0.554
Nr of predictions 3

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.19 0.25 0.15 5 4483 43 11 17 15 15
4ENB_A 0.81 0.73 0.92 11 460 3 0 1 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.