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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of Contrafold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & Contrafold [.zip] - may take several seconds...


Overview

Metric TurboFold(20) Contrafold
MCC 0.653 > 0.628
Average MCC ± 95% Confidence Intervals 0.668 ± 0.244 > 0.666 ± 0.272
Sensitivity 0.606 < 0.621
Positive Predictive Value 0.714 > 0.646
Total TP 80 < 82
Total TN 9208 > 9193
Total FP 42 < 59
Total FP CONTRA 11 < 19
Total FP INCONS 21 < 26
Total FP COMP 10 < 14
Total FN 52 > 50
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and Contrafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and Contrafold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and Contrafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and Contrafold).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 80
Total TN 9208
Total FP 42
Total FP CONTRA 11
Total FP INCONS 21
Total FP COMP 10
Total FN 52
Total Scores
MCC 0.653
Average MCC ± 95% Confidence Intervals 0.668 ± 0.244
Sensitivity 0.606
Positive Predictive Value 0.714
Nr of predictions 6

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of Contrafold - scored lower in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 82
Total TN 9193
Total FP 59
Total FP CONTRA 19
Total FP INCONS 26
Total FP COMP 14
Total FN 50
Total Scores
MCC 0.628
Average MCC ± 95% Confidence Intervals 0.666 ± 0.272
Sensitivity 0.621
Positive Predictive Value 0.646
Nr of predictions 6

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.68 0.69 0.69 20 1504 9 5 4 0 9
4A1C_2 0.21 0.25 0.19 5 4489 33 9 13 11 15
4AOB_A 0.53 0.52 0.56 15 1410 13 3 9 1 14
4ENB_A 0.85 0.73 1.00 11 461 1 0 0 1 4
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.